Enbrel® (etanercept) is a prescription medicine used to treat five chronic diseases, including moderate to severe rheumatoid arthritis. These highlights do not include all the information needed to use Enbrel safely and effectively. See full prescribing information for Enbrel. Enbrel® (etanercept). What is Enbrel (etanercept) and what is it used for? of Product Characteristics ( SPC) for Enbrel these can be found at the electronic Medicines Compendium.
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For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies. To find relevant articles please visit here to pick a cluster. Powder and solution for injection. Etanercept is a human tumour necrosis spv receptor p75 Fc fusion protein. It is a competitive inhibitor of TNF binding to cell surface receptors.
Treatment of active rheumatoid arthritis in adults when the response to disease modifying antirheumatic drugs, including methotrexate unless contraindicatedhas been inadequate.
Treatment of active polyarticular-course juvenile chronic arthritis in children aged four to 17 years who have had an inadequate response to, or who have proved intolerant of, methotrexate.
Hypersensitivity to active substance or excipients; sepsis or risk of sepsis. Treatment should not be initiated in patients with active infections, including chronic or localised infections. Treatment should be initiated and supervised by specialist physicians.
Enbrel 25mg is reconstituted with 1ml water for injections. Adults, recommended dose is 25mg etanercept administered twice weekly as a subcutaneous injection. Elderly 65 years and overno dosage adjustment required. Children and adolescents four to 17 years0. Children under four years, etanercept has not been studied. Renal and hepatic impairment, no dose adjustment required. Pregnancy, use is not recommended. Women of child-bearing potential should be advised not to get pregnant during use.
Lactation, excretion in human milk unknown see SPC.
No dose-limiting toxicities observed in trials. Patients who develop a new infection while undergoing treatment should be monitored closely.
Discontinue treatment if a serious infection develops. Caution needed when considering use in patients with a history of recurring infections or with underlying conditions which may predispose to infections, such as advanced or poorly controlled diabetes. Patients with significant exposure to varicella virus should temporarily discontinue etanercept envrel be considered for prophylactic treatment with varicella zoster immune globulin.
Live vaccines should not be given concurrently with etanercept.
Juvenile chronic arthritis patients should, if possible, be brought up to date with all immunisations prior to initiating therapy. The long term safety of etanercept in combination with other disease-modifying antirheumatic drugs has not been established.
Enbrel 25 mg powder and solvent for solution for injection
Interactions between etanercept and other drugs have not been evaluated in formal studies. Adults, injection site reactions, upper respiratory tract infections.
No increase in the incidence of serious infections was observed in trials. In postmarketing reports, serious infections have been reported. Impact of long term treatment on the development of autoimmune disease is unknown.
See SPC for details of other undesirable effects. psc
Juvenile chronic arthritis, in general, undesirable effects similar in frequency and type to those seen in adults. Headache, nausea, abdominal pain and vomiting were reported more commonly in juvenile chronic arthritis patients than in adults in trials. Wyeth says that supplies of etanercept are currently limited by manufacturing constraints and are unlikely to be sufficient to treat all suitable adult rheumatoid arthritis patients.
To ensure continuity of supply the company is maintaining enbre, record of patients prescribed etanercept by initials only and a special form has been designed to accompany each snbrel. For commenting, please login or register as a user and agree to our Community Guidelines.
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